Pyrrolidine, 2-(4-bromophenyl)-

Pyrrolidine, 2-(4-bromophenyl)- - Names and Identifiers

Name	2-(4-Bromophenyl)pyrrolidine
Synonyms	AKOS BB-8866 MFCD11506298 2-(4-Bromophenyl)pyrrolidine 2-(4-Bromo-Phenyl)-Pyrrolidine 2-(4-BROMO-PHENYL)-PYRROLIDINE Pyrrolidine, 2-(4-bromophenyl)- 4-(Pyrrolidin-3-yl)bromobenzene 1-Bromo-4-(pyrrolidin-2-yl)benzene 2-(4-BROMOPHENYL)PYRROLIDINE HYDROCHLORIDE
CAS	383127-22-8
InChI	InChI=1/C10H12BrN/c11-9-5-3-8(4-6-9)10-2-1-7-12-10/h3-6,10,12H,1-2,7H2

Pyrrolidine, 2-(4-bromophenyl)- - Physico-chemical Properties

Molecular Formula	C10H12BrN
Molar Mass	226.11
Density	1.369g/cm³
Boling Point	287.2°C at 760 mmHg
Flash Point	127.5°C
Vapor Presure	0.00252mmHg at 25°C
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Refractive Index	1.566

Pyrrolidine, 2-(4-bromophenyl)- - Introduction

2-(4-Bromophenyl)pyrrolidine is an organic compound with the chemical formula C11H13BrN. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: Colorless to pale yellow crystals.
-Solubility: Soluble in some organic solvents, such as ethanol, dichloromethane and methanol.
-Melting point: about 68-70 degrees Celsius.

Use:
-Medical field: 2-(4-Bromophenyl)pyrrolidine, as a selective inhibitor of dopamine transporter (DAT) in the brain, has potential antidepressant and anti-Parkinson's disease activity.
-Research: It is also used in dopamine receptor related experiments in biochemical research.

Preparation Method:
2-(4-Bromophenyl)pyrrolidine can be synthesized by the following steps:
1. First, pyrrolidine and acetone are hydrogenated in the presence of a nickel catalyst to obtain the corresponding dinitrile compound.
2. Then, the dinitrile is reacted with bromobenzene to generate lactam through S molecular lactam.
3. Finally, using acid catalysis, the lactam is hydrolyzed to obtain 2-(4-Bromophenyl)pyrrolidine.

Safety Information:
- 2-(4-Bromophenyl)pyrrolidine is an organic compound with certain potential hazards, so it needs to be used and handled under suitable laboratory conditions.
-During use, avoid direct contact with skin and eyes to avoid irritation or damage.
-Store and handle the compound properly to avoid contact with combustibles and oxidants.
-During operation, pay attention to the use of personal protective equipment, such as wearing appropriate gloves, protective glasses and laboratory coats.

Last Update：2024-04-09 21:01:54